These guidelines describe the clinical management of cases of COVID-19 disease, including clinical care in and outside of health facilities, and are intended for use in both public had private sectors. The guidelines are developed by the Clinical Guidelines Subcommittee of the National Department of Health’s Incident Management Team. They are informed by rapid medicine reviews conducted by the National Essential Medicines List Committee’s Subcommittee on COVID-19, as well as advisories provided by the Ministerial Advisory Committee on COVID-19. The following section/module has been updated or added as an annexure to the current guideline: Module 2 – Testing The guidelines are presented as modules in order to facilitate and expedite updating of individual sections in future. The National Department of Health is committed to providing regular updates for guidelines, as knowledge regarding strategies to address COVID-19 develop both globally and in South Africa.